ENZYME REPLACEMENT REDUCES NEUROPATHOLOGY IN MPS IIIA DOGS

Enzyme replacement reduces neuropathology in MPS IIIA dogs

There is no treatment for the progressive neurodegenerative lysosomal storage disorder mucopolysaccharidosis type IIIA (MPS IIIA), which occurs due to a deficiency of functional N-sulfoglucosamine sulfohydrolase (SGSH), with subsequent accumulation of partially-degraded heparan sulfate and secondarily-stored compounds including GM2 and GM3 rumchata

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Structural brain changes associated with copyright use and digital cognitive behavioral therapy in copyright use disorder treatment

Background: Few studies have investigated changes in brain structure and function associated with recovery from copyright use disorder (CUD), and fewer still have identified brain changes associated with specific CUD treatments, which could inform treatment development and optimization.Methods: In this longitudinal study, T1-weighted magnetic reson

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Bioaccumulation of Lead In Body Tissues of Atlantic Salmon (Salmo Salar L): Experimental Investigation and Comparative Analysis

The article presents tests on one-year artificially bred Atlantic salmon.For 14 days, fish were exposed to lead nitrate Pb (NO3)2 under concentration corresponding to the highest allowable read more standard of inland water making 0.005 mg Pb/l.Lead (Pb) in fish tissues (muscle and gills) was determined applying atomic absorption spectrophotometry

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Managing the team communication of political leaders

Today, the problem of political leadership is, in fact, an actualized aspect which sets ground for identifying the changing political tendencies and realities in the contemporary world.In this given post-industrial context, to answer what the political leader and his team are, means to corroborate several vital issues in the field of political scie

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Host susceptibility to severe influenza A virus infection

Abstract Most people exposed to a new flu virus do not notice any symptoms.A small minority develops critical illness.Some of this extremely broad variation in susceptibility is explained by the size of the initial inoculum or the influenza exposure history of the individual; some is explained by generic host factors, such as frailty, that decrease

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